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This pathway is regulated by an array of regulator proteins, including Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of Activated STATs (PIAS) and Protein Tyrosine Phosphatases (PTPs) determining the initiation, duration and termination of the signaling cascades. In this review, we represent how the JAK-STAT pathway is generally regulated and then in Th cell subsets in more detail.ĭysregulation of the JAK-STAT pathway in T helper cells may result in various immune disorders. Finally, we introduce novel targeted strategies as promising therapeutic approaches in the treatment of immune disorders.
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